PolyGalactose Magnetite™ is magnetic resonance imaging (MRI) reagent and is supplied as a lyophilized powder containing 200 mg of iron.  Reconstitute the product with 10 ml of distilled water to obtain a stable colloidal suspension containing 20 mg Fe/ml.  PolyGalactose Magnetite is based on the ultra-small superparamagnetic iron oxide (USPIO) reported by Josephson, et al. (1).  PolyGalactose Magnetite is surface funtionalized with arabinogalactan and is cleared from the vascular compartment by the asialoglycoprotein receptor as evidenced by blood clearance inhibition by asialofetuin but not fetuin.  PolyGalactose Magnetite is not withdrawn from the vascular compartment by cells of the macrophage-monocyte phagocytic system.  At 20 micromoles Fe/kg PolyGalactose Magnetite darkens MR images of the liver.  PolyGalactose Magnetite exhibits no acute toxicity when injected into rats at 1800 micromoles Fe/kg.

Physical Properties of PolyGalactose Magnetite™

References

1. Magnetic Resonance Imaging 8, 637 (1990)

Request for Additional Information and Pricing