spacer
BioPAL, Inc.
   diamond HOME     diamond ABOUT US    diamond ADVANTAGES OF BIOPAL    diamond WHAT'S NEW    diamond CONTACT    

New Ways to Make Measurements in the Life Sciences.

spacer
  diamond photo
pixel



Molday ION
Molday IONTM  Family of Products

The Product Pricing

Molday ION family of products and their price list.  NOT FOR HUMAN USE.
Download a PDF price list.
Download a PDF MSDS.
 

Technical Information

Molday ION™ is a 30 nm iron oxide-based superparamagnetic (USPIO) T2 relaxation-darkening contrast.  Molday ION, an intravascular contrast agent,  has a blood half-life of several hours and can be used in a wide range of cardiovascular and vascular research.

Molday ION Rhodamine B™ (MIRB), Molday ION EverGreen™, Molday ION Coumarin™are 35nm iron oxide-based superparamagnetic contrast reagent having a colloidal size of 35 nm.  These three colloids are designed for cell labeling and tracking and require no transfection reagents for efficient cell labeling.  The three colloids are cross-linked for stability and labeled with the fluorescent dyes Rhodamine B, EverGreen, or Coumarin exhibiting red, green and blue fluorescence, respectively.  They can be visualized by both MRI and fluorescence.  The three fluorophores have little spectral overlap allowing for flexibility in experiments and are compatible with fluorescent proteins, histological stains, and common optical filers.  (Rhodamine B: ex.555 nm; em.581 nm, EverGreen: ex.498 nm; em.526, Coumarin: ex.356 nm; em.456 nm)  In addition, we also offer Molday ION (-) a negative colloid formulated for labeling cells using Poly-L-Lysine.

Composite figure showing NIH-3T3 cells labeled with Molday ION Rhodamine B™ (MIRB), Molday ION EverGreen™, Molday ION Coumarin™

Molday ION C6Amine is engineered to have terminal amino groups with a C6 spacer.  It is designed for cell labeling and allows for efficient labeling with ligands, peptides, proteins, and nucleic acids (RNAi, DNA, etc.).  As a result, new biological properties can be conferred to the reagent, such as targeting to a specific receptor site.  These reagents are also classified as a darkening agent acting through the T2 relaxation process.

Molday ION Carboxyl Terminated nano-magnetite is specifically designed for conjugating your ligand, peptide, antibody, and protein using water soluble carbadiimide.  This T2 MRI contrast agent has a concentration of 2.5 mg Fe/ml, a size of ~30 nm, and a zeta potential of about -35 mV.  The nanoparticle is designed so that it is not bound to or internalized by cells allowing cell labeling exclusively from your conjugated ligand.  This product is well suited for cell targeting experiments!

Molday ION Rose Bengal the first commercially available theranostic for research applications.

Download a PDF picture of labeled cells!
Download a recent publication referencing Molday ION Rhodamine B™

Applications and Functionalities

Catalog No.

Name

Application

Functionality

CL-30Q02-2

Molday ION

Blood pool agent

Hydroxyl

CL-30Q02-6

Molday ION (-)

Cell labeling with PLL

Hydroxyl

CL-50Q02-6A

Molday ION C6Amine

1.  Cell labeling
2.  Conjugation

Amino

CL-30Q02-6C

Molday ION Carboxyl Terminated

1.  Cell labeling with PLL
2.  Conjugation

Carboxyl

CL-50Q02-6A-50

Molday ION Rhodamine B

Cell labeling

Rhodamine B

Physical properties

Catalog No.

Name

~Size
nm

~Zeta potential
mV

CL-30Q02-2

Molday ION

30

-4.8

CL-30Q02-6

Molday ION (-)

30

-15

CL-50Q02-6A

Molday ION C6Amine

35

48

CL-30Q02-6C

Molday ION Carboxyl Terminated

35

-38

CL-50Q02-6A-50

Molday ION Rhodamine B

35

31

Volume, Concentration and Price

Catalog No.

Name

Volume
ml

Concentration
mg Fe/ml

CL-30Q02-2

Molday ION

2

10

CL-30Q02-6

Molday ION (-)

2

10

CL-50Q02-6A

Molday ION C6Amine

2

5

CL-30Q02-6C

Molday ION Carboxyl Terminated

2

2.5

CL-50Q02-6A-50

Molday ION Rhodamine B

2

2

Download a Table of Relaxation Values

Helpful Download Files

Application Notes:
Receptor mediated endocytosis: Conjugation of spermidine to CL-30Q02-6C, a carboxyl containing USPIO
Download this PDF Application.

Cell labeling and tracking by MRI is a growing area of interest.  BioPAL provides a general method to label and fix cells using Molday ION product line.
Download a PDF method to label cell.
Download a PDF method to label cells with Molday ION Rhodamine B
Download a PDF method to fix cell.

BioPAL provides a method to label poly-l-lysine on to Molday ION (-) for cell labeling.
Download a PDF method for poly-lysine.
Download a PDF Cell labeling method and long-term stability.
Download a PDF of a recent published paper.

BioPAL provides a method to stain cells with Prussian Blue to visualize the presence of iron.
Download a PDF method for Prussian Blue Staining.

References
A list of reference can be found on the following page [Link]

 

Request for Additional Information and/or Ordering