Technical Information

BioPAL provides the research community with a comprehensive MRI product-line.  Galbumin™ is gadolinium-labeled albumin bottled at a concentration of 25 mg/ml.   There are approximately 10 to 15 gadolinium atoms per albumin unit and the molecular weight of the product is ~ 74k Da.

             2 mmol                                  0.037           0.37            1.84         3.68 mmol/l
Gado-DTPA    Water    ----------Galbumin-----------

 

The above Figure was generated using Spin Echo (SE) sequence with TR/TE = 100/14, images of gadolinium labeled solutions in microtubes were obtained.  The average signal intensity within a region-of-interest (ROI) is as follows: A=106, B=9, C=16, D=38, E=90, F=94.  The background intensity measured is 0.7.

In addition, BioPAL also provides two additional Galbumin products: Trackable Galbumin™ and Glowing Galbumin™.  Trackable Galbumin is gadolinium-labeled albumin laced with europium to permit tracking via BioPAL's neutron activation service.  Glowing Galbumin is gadolinium-labeled albumin that is co-labeled with FITC for fluorescent imaging.

The Product

One ml of Galbumin, Trackable Galbumin, or Glowing Galbumin is packaged in a 2 ml sealed serum bottles at a concentration of 25 mg/ml.  Applications include vascular imaging and injection and injection-site visualization.  Suggested starting dose for rats and mice is 2-4 ml/kg.  NOT FOR HUMAN USE.
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Reference
Download a PDF of a recent publication - 1
Download a PDF of a recent publication - 2
Download a PDG of a recent publication - 3

1.  NMR in Biomedicine 2008 21(9):941-956.
2.  Exp Eye Res 2009 88(3):418-425.