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BioPAL, Inc.
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New Ways to Make Measurements in the Life Sciences.

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Cell Labeling and Tracking

The twenty-first century began with the completion of the human genome project and the dawn of proteomics and systems-biology.  These emerging fields will attempt to understand how newly discovered proteins impact human physiology and disease.  As researchers progress from molecular- and cellular-based studies to in vivo systems, innovative technologies are needed to allow multiple tracking of probes and multiple measurements of functional parameters in in vivo models.  One arena of research that has emerged due to recent discoveries is the field of cellular transplantation.

BioPAL has developed CELLTrack™ to aid researchers locate, track, and quantify implanted cells in in vivo systems.  We currently offer seven different colloidal markers, with additional markers under development. Cellular uptake is via a variety of mechanisms following the incubation of cells with CELLTrack. Independent researchers have reported successful application of this product using a variety of different cell lines.  We can also provide targeted material directed to specific receptors to maximize cellular uptake for specific cell lines on a custom basis.

Several of the lanthanide labels can also be measured by time-resolved fluorescent technology and by magnetic resonance imaging (MRI).  Therefore, researchers can take advantage of one, two or all three technologies to maximize data output.  As a expansion on this theme, BioPAL offers CELLTrack that is co-labeled with rhodamine or fluorescein to provide researchers the ability to visualize cells by conventional fluorescent techniques.

Development of this product line has, in part, been supported by a National Institutes of Health (NIH) Small Business Innovation Research (SBIR) grant sponsored.  See What's New!

The Advantages

Non-radioactive:  All of BioPAL's products are stable and non-radioactive.  As a result, this product is not a radiological toxin to the cells being labeled and the user will not require special licensing to use these products.
High Sensitivity:
  Depending on the labeling efficiency which is dependent on many factors, CELLTrack offers high sensitivity via neutron activation technology.  For example, the measurement of one labeled cell in a gram sample is theoretically achievable.
Quantitative Measurement:
  Unlike many fluorescent-based cell labeling methods for in vivo applications, CELLTrack provides a quantified measure directly from intact tissue, urine, blood, and/or fecal samples.  No extraction! No sample loss!
Electron Dense:
  The colloidal-based product lines can be visualized using electron microscopy (EM).
Magnetic Resonance Imaging:
  In addition to neutron activation technology, several of the CELLTrack products can be imaged via MRI.  See our Molday USMIO Product line.
Fluorescent Technology:
  In addition to neutron activation technology, several of the CELLTrack products can be visualized by fluorescent techniques and can be assayed by time-resolved fluorescent technology.
Experimental Flexibility:
  By using different labels, CELLTrack can be used in combination with other BioPAL products, such as our microspheres, to provide greater experimental design flexibility.

Customer Reference list

Download a recent poster presentation that was presented at the 2007 European Society of Cardiology Congress in Vienna, Austria by MG Biotherapeutic, which is a joint venture between Medtronic and Genzyme.  In addition, we have compiled a brief list of references from researchers that have used and cited BioPAL products.  Here's the link to the PDF file.  If you would like to include your published research in our reference list, please contact us.

The Product

  1. Colloid Cell Labeling Products
    Currently, three different colloidal markers are available with additional markers under development.  The first is a 30 nm gold colloid packaged in a 2 ml sealed serum bottle and the second is a 300 nm iridium colloid packaged in a 2ml sealed serum bottle.  The third is a 600 nm colloids packaged in a 2ml sealed serum bottle. (Patent Pending)
    Download a PDF colloid price list.
    Download a PDF IVST price list.
    Download a PDF MSDS colloids.
    Download a PDF MSDS IVST.

     
  2. Contaminant-Free, Sample Vials
    BioPAL's polypropylene sample vials are cleaned to remove trace contamination and are calibrated for our activation and counting system.  These vials must be used for the assay.
    Download a PDF price list.
     
  3. Saline-Free Buffer
    BioPAL offers sansSaLine, a saline-free buffer, to wash and clean samples to minimize sodium background activity, thereby maximizing the sensitivity of the measurement.
    Download a PDF price list.
    Download a PDF MSDS sansSaLine.
     
  4. Assay Service
    BioPAL charges a per-sample assay fee for our neutron activation assay service.  The results of the assay are reported as the total disintegrations per minute (dpm) measured in each sample for each corresponding isotopic label.
    Download a PDF price list.
    Download a PDF Assay Request Form.

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